Unlockable difficulty levels
Unlockable How to Unlock
Son of Sparda mode Beat Devil Hunter mode
Dante Must Die mode Beat Son of Sparda mode
Heaven or Hell mode Beat Son of Sparda mode
Hell and Hell mode Beat Dante Must Die mode
Unlockable artwork
Unlockable How to Unlock
The Two Heroes; 29 character images Beat Human or Devil Hunter mode
The Cast Beat Devil Hunter mode
The Demons; 12 publicity pictures Beat Son of Sparda mode
Demon Invasion Beat Dante Must Die mode
The Ladies of Devil May Cry Beat Heaven or Hell mode
Light from the Demon Blade Beat Hell or Hell mode
Complete Ending
After beating Devil May Cry 4 and viewing part of the ending, the credits roll. During this time you have to protect Kyrie from being hit or the credits will end prematurely.

Unlockable How to Unlock
See the rest of the ending Protect Kyrie during the Credits for 90 seconds.
Super Costumes
Unlock Super Nero & Dante

Unlockable How to Unlock
Super Nero Beat Dante must Die mode
Super Dante Beat Dante must Die mode
Unlock the Bloody Palace
The Bloody Palace makes it's return.

Unlockable How to Unlock
Bloody Palace Beat Devil Hunter Mode